Role of tight junction proteins in gastroesophageal reflux disease
نویسندگان
چکیده
منابع مشابه
Role of tight junction proteins in gastroesophageal reflux disease
BACKGROUND Gastroesophageal reflux disease (GERD) is associated with impaired epithelial barrier function that is regulated by cell-cell contacts. The aim of the study was to investigate the expression pattern of selected components involved in the formation of tight junctions in relation to GERD. METHODS Eighty-four patients with GERD-related symptoms with endoscopic signs (erosive: n = 47) ...
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TO THE EDITOR: I read with great interest the study by Liu et al regarding the significant correlation between presence of desmosomal junction alterations and the severity of gastroesophageal reflux disease (GERD). The authors reported that tight-junction proteins (TJP) such as claudin-1 and claudin-2 were abundant not only in asymptomatic controls but also in patients with gastroesophageal ref...
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Background/Aims Eosinophilic esophagitis (EoE) is often erroneously diagnosed as gastroesophageal reflux disease (GERD). The aim of this study is to investigate the prevalence of EoE and the expression of tight junction (TJ) proteins in patients with GERD symptoms. Methods One hundred patients with GERD symptoms and 10 healthy controls were prospectively studied. Sixty-two patients had sympto...
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TO THE EDITOR: Gastroesophageal reflux disease (GERD) and its complications are increasingly recognized in many parts of Asia, largely due to an increasing prevalence of obesity. Obese subjects are found to have frequent transient lower esophageal sphincter (LES) relaxations (TLESRs) and more likely to reflux with underlying mechanisms being unclear. Besides the circular muscle, recent evidence...
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TO THE EDITOR: I appreciate the interest and comments on our paper, which was published in the July 2013 issue of this journal. As you have commented, hiatus hernia is an important factor in the pathogenesis of gastroesophageal reflux disease (GERD). Especially, the elderly patients with GERD have high possibility for accompanying hiatus hernia. Our study was performed in 9 patients with GERD a...
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ژورنال
عنوان ژورنال: BMC Gastroenterology
سال: 2012
ISSN: 1471-230X
DOI: 10.1186/1471-230x-12-128